Biology and Evolution of Symbiosis (BESymb)
Research articles
2025
Willemsen A*, Manzano-Marín A, Horn M. Novel high-quality amoeba genomes reveal widespread codon usage mismatch between giant viruses and their hosts. Genome Biology and Evolution, 17(1):evae271. doi: 10.1093/gbe/evae271. bioRχiv: 10.1101/2024.09.23.614596.
2024
Rogowska-van der Molen MA, Manzano-Marín A, Postma JL, Coolen S, van Alen T, Jansen RS, Welte CU*. From eggs to guts: Symbiotic association of Sodalis nezarae sp. nov. with the Southern green shield bug Nezara viridula. Preprint. bioRχiv: 10.1101/2024.10.18.619066.
Jousselin E*, Coeur d’acier A, Clamens A-L, Galan Maxime, Cruaud C, Barbe V, and Manzano-Marín A*. Discordance between mitochondrial, nuclear, and symbiont genomes in aphid phylogenetics: who is telling the truth?. Zoological Journal of the Linnean Society, 201(4):zlae098. doi: 10.1093/zoolinnean/zlae098. bioRχiv: 10.1101/2024.04.12.589189.
Sosa-Jiménez VM, Kvist S, Manzano-Marín A*, and Oceguera-Figueroa A*. Discovery of a novel symbiotic lineage associated with a haematophagous leech from the genus Haementeria. Microbiology Spectrum, e04286-23. doi: 10.1128/spectrum.04286-23. bioRχiv: 10.1101/2023.12.21.572949.
2023
Manzano-Marín A*, Kvist S, and Oceguera-Figueroa A*. Evolution of an alternative genetic code in the Providencia symbiont of the haematophagous leech Haementeria acuecueyetzin. Genome Biology and Evolution, 15(9):evad164. doi: 10.1093/gbe/evad164. bioRχiv: 10.1101/2023.03.27.534433.
Manzano-Marín A*, Coeur d’acier A, Clamens A-L, Cruaud C, Barbe V, and Jousselin E. Co-obligate symbioses have repeatedly evolved across aphids, but partner identity and nutritional contributions vary across lineages. Peer Community Journal, 3:e46. doi: 10.24072/pcjournal.278. bioRχiv: 10.1101/2022.08.28.505559.
Halter T, Köstlbacher S, Rattei T, Hendrickx F, Manzano-Marín A*, and Horn M. One to host them all: genomics of the diverse bacterial endosymbionts of the spider Oedothorax gibbosus. Microbial Genomics, 9(2):000943. doi: 10.1099/mgen.0.000943. bioRχiv: 10.1101/2022.05.31.494226.
2022
Halter T, Hendrickx F, Horn M, and Manzano-Marín A*. A novel widespread MITE element in the repeat-rich genome of the Cardinium endosymbiont of the spider Oedothorax gibbosus. Microbiology Spectrum, 10(6):e02627-22. doi: 10.1128/spectrum.02627-22. bioRχiv: 10.1101/2022.06.21.494476.
Smith G, Manzano-Marín A, Reyes-Prieto M, Ribeiro Antunes CS, Ashworth V, Goselle ON, Jan AAA, Moya A, Latorre A, Perotti MA*, and Braig HR. Human follicular mites: Ectoparasites becoming symbionts. Molecular Biology and Evolution, 39(6):msac125. doi: 10.1093/molbev/msac125. Shared 1st authorship.
- News coverage (selected): EurekAlert! (AAAS), BBC, The Guardian, COSMOS, IFL Science, BIG Think, New York Post, Discover, The Telegraph, NPR, National Geographic España, Le Monde, Der Standard, APA, FOCUS, ORF, Krone, Spektrum.
Vittecoq M*, Brazier L, Elguero E, Bravo IG, Renaud N, Manzano-Marín A, Prugnolle F, Godreuil S, Blanchon T, Roux F, Durand P, Renaud F, and Thomas F. Multiresistant Enterobacteriaceae in yellow‐legged gull chicks in their first weeks of life. Ecology and Evolution, 12(6):e8974. doi: 10.1002/ece3.8974. Dryad dataset: 10.5061/dryad.fxpnvx0vf.
Szabó G*, Schulz F, Manzano-Marín A, Toenshoff ER, and Horn M. Evolutionary recent dual obligatory symbiosis among adelgids indicates a transition between fungus and insect associated lifestyles. The ISME Journal, 16(1):247-256. doi: 10.1038/s41396-021-01056-z. bioRχiv: 10.1101/2020.10.16.342642.
2021
Ün C, Schultner E*, Manzano-Marín A, Flórez L, V, Heinze J, and Oettler J*. Cytoplasmic incompatibility between Old and New World populations of a tramp ant. Evolution, 75(7):1775-1791. doi: 10.1111/evo.14261. bioRχiv: 10.1101/2020.03.13.988675. Zenodo dataset: 10.5281/zenodo.3561160.
2020
Sosa-Jiménez VM, Torres-Carrera G, Manzano-Marín A, Kvist S, and Oceguera A*. Mitogenome of the blood feeding leech Haementeria acuecueyetzin (Hirudinida: Glossiphoniidae) from Tabasco, Mexico. Mitochondrial DNA Part B, 5(3):3328-3330. doi: 10.1080/23802359.2020.1814888.
Kvist S*, Manzano-Marín A, de Carle D, Trontelj P, and Siddall ME. Draft genome of the European medicinal leech Hirudo medicinalis (Annelida, Clitellata, Hirudiniformes) with emphasis on anticoagulants. Scientific Reports, 10(1):9885. doi: 10.1038/s41598-020-66749-5. Zenodo dataset: 10.5281/zenodo.3555585.
→News coverage: Forbes, EurekAlert! (AAAS), Phys.org, ScienMag, GenomeWeb, U.S. News & World Report, Drugs.com, HealthDay, DoctorsLounge, and Sci-News.com. Blogs: DNA Science Blog (PLoS) and Bioengineer.
Rouïl J, Jousselin E, Coeur d’acier A, Cruaud C, and Manzano-Marín A*. The protector within: Comparative genomics of APSE phages across aphids reveals rampant recombination and diverse toxin arsenals. Genome Biology and Evolution, 12(6):878-889. doi: 10.1093/gbe/evaa089. bioRχiv: 10.1101/2020.03.17.996009. Zenodo dataset: 10.5281/zenodo.3764739. Shared 1st authorship. PhD. student paper.
Manzano-Marín A*. No evidence for Wolbachia as a nutritional co-obligate endosymbiont in the aphid Pentalonia nigronervosa. Microbiome, 8:72. doi: 10.1186/s40168-020-00865-2. bioRχiv: 10.1101/609511. Zenodo dataset: 10.5281/zenodo.2640354. * Critical review showing contradictory results to those of de Clerck et. al. 2015 Microbiome 3(1): 63.
Manzano-Marín A*, Coeur d’acier A, Clamens A-L, Orvain C, Cruaud C, Barbe V, and Jousselin E. Serial horizontal transfer of vitamin-biosynthetic genes enables the establishment of new nutritional symbionts in aphids’ di-symbiotic systems. The ISME Journal, 14(1):259-273. doi: 10.1038/s41396-019-0533-6. bioRχiv: 10.1101/556274. Zenodo dataset: 10.5281/zenodo.2566355.
2019
Patel V, Chevignon G, Manzano-Marín A, Brandt JW, Strand MR, Russell JA, and Oliver KM*. Cultivation-assisted genome of Candidatus Fukatsuia symbiotica; the enigmatic ‘X-type’ symbiont of aphids. Genome Biology and Evolution, 11(12):3510-3522. doi: 10.1093/gbe/evz252.
2018
Manzano-Marín A*, Coeur d’acier A, Clamens A.-L, Orvain C, Cruaud C, Barbe V, and Jousselin E. A Freeloader? The highly eroded yet large genome of the Serratia symbiotica symbiont of Cinara strobi. Genome Biology and Evolution, 10(9):2178-2189. doi: 10.1093/gbe/evy173. bioRχiv: 10.1101/305458.
2017
Meseguer AS*, Manzano-Marín A, Coeur d’Acier A, Clamens A-L, Godefroid M, and Jousselin E. Buchnera has changed flatmate but the repeated replacement of co-obligate symbionts is not associated with the ecological expansions of their aphid hosts. Molecular Ecology, 26(8):2363-2378. doi: 10.1111/mec.13910. bioRχiv: 10.1101/086223. Perspective: 10.1111/mec.14047. PDF
Manzano-Marín A, Szabó G, Simon J-C, Horn M, and Latorre A*. Happens in the best of subfamilies: establishment and repeated replacements of co-obligate secondary endosymbionts within Lachninae aphids. Environmental Microbiology, 19(1):393-408. doi: 10.1111/1462-2920.13633. bioRχiv: 10.1101/059816. Highlighted: 10.1111/1462-2920.13516. PDF
2016
Manzano-Marín A* and Latorre A. Snapshots of a shrinking partner: Genome reduction in Serratia symbiotica. Scientific Reports, 6:32590. doi: 10.1038/srep32590. bioRχiv: 10.1101/057653.
Manzano-Marín A, Simon J.-C, and Latorre A*. Reinventing the wheel and making it round again: Evolutionary convergence in Buchnera–Serratia symbiotic consortia between the distantly related Lachninae aphids Tuberolachnus salignus and Cinara cedri. Genome Biology and Evolution, 8(5):1440-1458. doi: 10.1093/gbe/evw085.
Oceguera-Figueroa A*, Manzano-Marín A, Kvist S, Moya A, Siddall ME, and Latorre A. Comparative mitogenomics of leeches (Annelida: Clitellata): Genome conservation and Placobdella-specific trnD gene duplication. PLoS ONE, 11(5):e0155441. doi: 10.1371/journal.pone.0155441. Shared 1st authorship.
Klein A, Schrader L, Gil R, Manzano-Marín A, Flórez L, Wheeler D, Werren J. H, Latorre A, Heinze J, Kaltenpoth M, Moya A, and Oettler J*. A novel intracellular mutualistic bacterium in the invasive ant Cardiocondyla obscurior. The ISME Journal, 10(2):376-388. doi: 10.1038/ismej.2015.119.
2015
Manzano-Marín A, Oceguera-Figueroa A*, Latorre A, Jiménez-Garcı́a L. F, and Moya A. 2015. Solving a bloody mess: B-vitamin independent metabolic convergence among gammaproteobacterial obligate endosymbionts from blood-feeding arthropods and the leech Haementeria officinalis. Genome Biology and Evolution, 7(10):2871-2884. doi: 10.1093/gbe/evv188. Shared 1st authorship.
2014-2011
Manzano-Marín A and Latorre A*. Settling down: The genome of Serratia symbiotica from the aphid Cinara tujafilina zooms in on the process of accommodation to a cooperative intracellular life. Genome Biology and Evolution, 6(7):1683-1698. doi: 10.1093/gbe/evu133.
Manzano-Marín A, Lamelas A, Moya A, and Latorre A*. Comparative genomics of Serratia spp.: Two paths towards endosymbiotic life. PLoS ONE, 7(10):e47274. doi: 10.1371/journal.pone.0047274.
Lamelas A, Gosalbes M. J, Manzano-Marín A, Peretó J, Moya A, and Latorre A*. Serratia symbiotica from the aphid Cinara cedri: A missing link from facultative to obligate insect endosymbiont. PLoS Genetics, 7:e1002357. doi: 10.1371/journal.pgen.1002357.
Review articles
2017
Latorre A and Manzano-Marín A. Dissecting genome reduction and trait loss in insect endosymbionts. Annals of the New York Academy of Sciences, 1389(1):52-75. doi: 10.1111/nyas.13222. PDF
Post-publication reviews
2020
Monnin D et. al. Parallel evolution in the integration of a co-obligate aphid symbiosis. Current Biology, 30(10):1949-1957. doi: 10.1016/j.cub.2020.03.011.
The paper describes an independently evolved co-obligate symbiosis in Periphyllus aphids, but fails to provide compelling or conclusive evidence for A. urticata and M. carnosum. The full review can be read at PubPeer.